Ion-Exchange HPLC Column
Ion-Exchange HPLC Column
Biovanix IEX columns are engineered on a highly modified, ultra-pure silica matrix, specifically designed for high-resolution separation of proteins and ionic compounds. Our comprehensive portfolio, ranging from weak cation to strong anion exchangers, enables precise characterization of charge heterogeneity in biopharmaceuticals.
Product Portfolio
Weak Cation Exchange (WCX): Features carboxylic acid-modified silica. Optimized for separating charge variants of monoclonal antibodies (mAbs), making it the ideal choice for protein drug quality control.
Strong Cation Exchange (SCX): Utilizes a sulfonic acid-modified silica matrix. Provides robust cation exchange for the separation and purification of various cationic analytes.
Strong Anion Exchange (SAX): Employs a quaternary ammonium-modified silica matrix, delivering exceptional separation performance for anionic analytes.
Core Advantages
Superior Selectivity: Optimized for antibody charge variants (acidic/basic peaks), providing industry-leading resolution.
Excellent Peak Shape & Low Carryover: Advanced surface modification minimizes non-specific adsorption, ensuring peak symmetry and reducing cross-contamination risks.
High Efficiency & Mechanical Strength: The high-performance silica matrix maintains structural integrity and separation efficiency even at high flow rates.
Broad Robustness: Excellent tolerance to acids, bases, and organic solvents, compatible with diverse mobile phases and Clean-in-Place (CIP) protocols.
Exceptional Reproducibility: Stringent batch-to-batch control ensures consistent column performance, facilitating seamless method development and transfer.
Product Parameter
Product Name |
WCX Column |
SCX Column |
SAX Column |
Functional Group |
Carboxylic Acid |
Sulfonic Acid |
Quaternary Ammonium |
Substrate |
Monodispersed spherical PS/DVB particles |
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Particle Size |
5 & 10 μm |
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Pore Size |
Nonporous |
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Pressure Limit |
4500 psi for 10 μm; 5000 psi for 5 μm |
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Temperature Limit |
60℃ |
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pH Range |
2-12 |
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